Hemodynamic effects of amiodarone.

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PM101: a cyclodextrin-based intravenous formulation of amiodarone devoid of adverse hemodynamic effects.

Intravenous amiodarone (Amiodarone i.v.) is widely used to treat cardiac arrhythmias. The most frequent clinical adverse event associated with Amiodarone i.v. administration is systemic hypotension which has been attributed to the cosolvents used in the formulation, polysorbate 80 and benzyl alcohol. To minimize hypotension Amiodarone i.v. is diluted in 5% dextrose in water prior to administrat...

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The effects of continuous rate infusion of lidocaine or amiodarone on hemodynamic and arrhythmias induced by epinephrine in dogs anesthetized with halothane were evaluated. Thirty dogs were distributed into three groups: amiodarone group (AG), lidocaine group (LG), or control group (CG). Anesthesia was induced with etomidate and maintained with halothane. Thirty minutes later a bolus and contin...

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The Effects of Amiodarone of Rabbit Lung Alveolar Cells

Purpose: The effects of Amiodarone on lung tissue and morphologic changes of alveolar cells. Materials and Methods: in this study, we used 21 mature male rabbits and they were divided into control and two experimental groups. Daily 80 mg/kg amiodarone was injected intra peritoneally to the experimental animals for one or two weeks. The control group received normal saline the same dose as amio...

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Side effects with amiodarone therapy.

Amiodarone hydrochloride is increasingly being used in the treatment of ventricular and supraventricular arrhythmias. Although a highly effective anti-arrhythmic agent, its use is restricted by the high incidence of side effects. To elucidate the value of monitoring serum level of both the parent drug and its active metabolite in predicting the occurrence of side effects, the investigators exam...

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The effects of amiodarone on thyroid function tests in 100 patients treated for 6 weeks to 8 years are reported. One patient became thyrotoxic and 10 developed latent or overt hypothyroidism. Twenty-five patients remained clinically euthyroid throughout, but had free thyroxine indices above the normal range. In these patients with apparently anomalous results, total tri-iodothyronine was normal...

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ژورنال

عنوان ژورنال: Circulation

سال: 1980

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.62.3.666